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Endometrial Cancer: Understanding, Causes, Diagnosis, Symptoms and Treatment

Endometrial cancer is the incidence of violence on the inside lining of the uterus (endometrium). Endometrial cancer is also known as uterine cancer. In the menstrual cycle, hormonal factors causing changes in the lining of the endometrium of the uterus. Prior to ovulation, the ovaries (ovarian) will produce the hormone estrogen which causes the thickening of the endometrium. This thickening is important to provide nutrients for the fetus in case of pregnancy.


If pregnancy does not occur after ovulation, the estrogen production wills increasingly decline and an increase in the production of the hormone progesterone. At the end of the cycle, the lining of the endometrium decays and out as menstruation (if pregnancy does not occur). There is no exact cause of emergence of endometrial cancer. However, there are some risk factors that are thought to relate to the risk of the emergence of endometrial cancer, among other things:

1. Circumstances that affect hormonal amounts during life
Hormonal therapy (estrogen) after menopause, the number of menstrual cycles a lot (e.g. early menarche or slow menopause) and some types of ovarian tumors, PCOS can increase the risk. Pregnancy and combined hormonal family planning can reduce risk.

2. The use of IUD (Intra Uterine Device)/AKDR (Contraceptives in the womb), a non-hormonal IUD users have a smaller risk
Age may increase the risk.

3. Diet, exercising habits, foods high in fat and daily life can increase the risk of

4. Diabetes, women with diabetes are more at risk of up to 4 x for developing cancer of the endometrium

5. Family history (especially with a history of endometrial cancer or colorectal cancer) can increase the risk of

6. A history of diagnosed with ovarian or breast cancer earlier can increase the risk of

7. A history of Endometrial hyperplasia with previously diagnosed may increase the risk of

8. Radiation in the pelvic area (e.g. for handling other cancer in the pelvic area) will increase the risk of

But keep in mind that having a risk factor does not mean you will be exposed to endometrial cancer. In determining a diagnosis of endometrial cancer, needed a series of medical interview and physical examination to evaluate signs and symptoms are experienced. Moreover, it can do some ancillary inspection, such as:

1. Ultrasonography (USG): performed to assess the structure. Generally it will be advisable to do a trans-vaginal ultrasound to assess whether there is a period in the uterus or an endometrial thickening.

2. Endometrial sampling: doctors can perform endometrial sampling through biopsy, Hysteroscopy, or curettage. These samples will be evaluated by a pathologist with the aid of a microscope to assess the presence of cancer cells.

3. CA-125: many (but not all) types of endometrial cancer are releasing these substances into the blood. The high figures are generally described the spread of cancer passed utero. CA-125 is generally examined to evaluate the success of the therapy.

4. Inspection: the inspection can be carried out to assess whether cancer cells have spread to other parts of the body, in the case of endometrial cancer. The examination may be conducted is a chest x-ray, CT-Scan, MRI, PET scan.

The stadium holds an important role in cancer diagnosis and treatment planning, stage endometrial cancer are as follows:

Stage 1: cancer is found in an area in the womb
Stage 2: the cancer spread to the cervix (cervical)
Stage 3: the cancer spread to tissues around the outside of the uterus as a network in the pelvis or lymph nodes
Stage 4: the cancer spread to the tissues in the abdomen, or other organs such as the bladder, intestines, liver, and lungs

Some symptoms of endometrial cancer that can be identified as follows:

1. Abnormal Bleeding from v*gina: in women who have not yet menopausal flecks can be either between the time of menstruation, menstrual changes, suppose a lot more than usual, etc. Generally a woman who is diagnosed with endometrial cancer has experienced menopause (75%), so the complaint is bleeding from the v*gina even though no menstruation. Note abnormal bleeding can be caused by other things such as endometriosis or polyps, but should always be evaluated further.
2. Pain in the lower back, legs, or pelvis.
3. Loss of appetite and weight loss that cannot be explained.

Treatment greatly influenced the type of cancer and stage of cancer when diagnosed. Some therapies that can be recommended are:

1. Surgery: retrieval of tissues affected by cancer such as the Act of a hysterectomy (uterus Rapture), Rapture peak v*gina and abnormal lymph nodes
2. Radiation Therapy: the use of high energy x-rays to kill cancer cells
3. Hormonal therapy
4. Chemotherapy: the use of a drug that is included in the veins to kill cancer cells

Treatment can also be done with a combination of multiple therapies such as surgery followed by radiation therapy.
Tag : Cancer
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