If pregnancy does not occur after ovulation, the estrogen production wills increasingly decline and an increase in the production of the hormone progesterone. At the end of the cycle, the lining of the endometrium decays and out as menstruation (if pregnancy does not occur). There is no exact cause of emergence of endometrial cancer. However, there are some risk factors that are thought to relate to the risk of the emergence of endometrial cancer, among other things:
1. The use of IUD (Intra Uterine Device)/AKDR (Contraceptives in the womb), a non-hormonal IUD users have a smaller risk
Age may increase the risk.
2. Circumstances that affect hormonal amounts during life
Hormonal therapy (estrogen) after menopause, the number of menstrual cycles a lot (e.g. early menarche or slow menopause) and some types of ovarian tumors, PCOS can increase the risk. Pregnancy and combined hormonal family planning can reduce risk.
3. Diabetes, women with diabetes are more at risk of up to 4 x for developing cancer of the endometrium
4. Diet, exercising habits, foods high in fat and daily life can increase the risk of
5. A history of diagnosed with ovarian or breast cancer earlier can increase the risk of
6. Family history (especially with a history of endometrial cancer or colorectal cancer) can increase the risk of
7. Radiation in the pelvic area (e.g. for handling other cancer in the pelvic area) will increase the risk of
8. A history of Endometrial hyperplasia with previously diagnosed may increase the risk of
But keep in mind that having a risk factor does not mean you will be exposed to endometrial cancer. In determining a diagnosis of endometrial cancer, needed a series of medical interview and physical examination to evaluate signs and symptoms are experienced. Moreover, it can do some ancillary inspection, such as:
1. Endometrial sampling: doctors can perform endometrial sampling through biopsy, Hysteroscopy, or curettage. These samples will be evaluated by a pathologist with the aid of a microscope to assess the presence of cancer cells.
2. Ultrasonography (USG): performed to assess the structure. Generally it will be advisable to do a trans-vaginal ultrasound to assess whether there is a period in the uterus or an endometrial thickening.
3. Inspection: the inspection can be carried out to assess whether cancer cells have spread to other parts of the body, in the case of endometrial cancer. The examination may be conducted is a chest x-ray, CT-Scan, MRI, PET scan.
4. CA-125: many (but not all) types of endometrial cancer are releasing these substances into the blood. The high figures are generally described the spread of cancer passed utero. CA-125 is generally examined to evaluate the success of the therapy.
The stadium holds an important role in cancer diagnosis and treatment planning, stage endometrial cancer are as follows:
Stage 1: cancer is found in an area in the womb
Stage 2: the cancer spread to the cervix (cervical)
Stage 3: the cancer spread to tissues around the outside of the uterus as a network in the pelvis or lymph nodes
Stage 4: the cancer spread to the tissues in the abdomen, or other organs such as the bladder, intestines, liver, and lungs
Some symptoms of endometrial cancer that can be identified as follows:
1. Abnormal Bleeding from vagina: in women who have not yet menopausal flecks can be either between the time of menstruation, menstrual changes, suppose a lot more than usual, etc. Generally a woman who is diagnosed with endometrial cancer has experienced menopause (75%), so the complaint is bleeding from the vagina even though no menstruation. Note abnormal bleeding can be caused by other things such as endometriosis or polyps, but should always be evaluated further.
2. Pain in the lower back, legs, or pelvis.
3. Loss of appetite and weight loss that cannot be explained.
Treatment greatly influenced the type of cancer and stage of cancer when diagnosed. Some therapies that can be recommended are:
1. Radiation Therapy: the use of high energy x-rays to kill cancer cells
2. Surgery: retrieval of tissues affected by cancer such as the Act of a hysterectomy (uterus Rapture), Rapture peak vagina and abnormal lymph nodes
3. Chemotherapy: the use of a drug that is included in the veins to kill cancer cells
4. Hormonal therapy
Treatment can also be done with a combination of multiple therapies such as surgery followed by radiation therapy.